Mobirise Website Builder

Our Research

Our research group performs a variety of studies in the general areas of inorganic, bioinorganic, medicinal, materials, and supramolecular chemistry.  Some of our current focus areas are summarized below

Mobirise Website Builder

Metal-Organic Frameworks

For more than 15 years our group has explored the chemistry of the microporous solids known as metal-organic frameworks (MOFs).  Our studies have spanned a wide range of topics with MOFs, largely focusing on synthetic methods, including postsynthetic modification (PSM).  Many of our more recent studies have been focused on MOF-polymer composite materials and low-valent MOFs.

Mobirise Website Builder

Metalloenzyme Inhibitors

For more than 20 years our group has developed approaches to apply fragment-based drug discovery (FBDD) to the development of metalloenzyme inhibitors. Our studies have targeted metalloenzymes implicated in a wide range of illness, from cancer to infectious disease. Many of our more recent studies have been focused the development of metal-binding isosteres (MBIs) and targeted protein degradation (TPD) of metalloenzymes.

Mobirise Website Builder

Metallofragments

Within the last 4 years our group has explored the use of 'metallofragments' for fragment-based drug discovery (FBDD). Metallofragments seek to exploit the inherent 3-dimensionality and reactivity of metal complexes for discovering new bioactive molecules.  Our studies have examined a variety of disease-relevant targets, including the main protease of SARS-CoV-2 (e.g., COVID-19).

Mobirise Website Builder

Other Projects

Over the course of our investigations, our group has explored a variety of topics in bioinorganic, medicinal, inorganic, materials, and supramolecular chemistry.  Some of these led to larger projects, while others consisted of just short-term or one-off studies..

Best AI Website Creator