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Research Publications

Our research group seeks to be productive, publishing the highest quality work possible.  We strive to ensure reproducibility of our results and rapid disclosure of our findings.  Find our publications from the last several years listed below and a complete list on Google Scholar via the button below.


273. Alysia Kohlbrand, Ryjul Stokes, Banumathi Sankaran, and Seth M. Cohen*, "Structural Studies of Inhibitors with Clinically-relevant Influenza Endonuclease Variants" Biochemistry 2023, in revision. DOI: ??????????????

272. Prantik Mondal, Zheng, Klaus Schmidt-Rohr, and Seth M. Cohen*, "Accessing Benzylic Amine and Azide Chemical Handles in Canonical Metal-Organic Frameworks" Chem. Mater. 2023, accepted for publication. DOI: 10.1021/ACS.CHEMMATER.3C02143

271. Michelle R. Doyle, Selen Dirik, Angelica R. Martinez, Elizabeth A. Sneddon, Hyeonglim Seo, Seth M. Cohen, and Giordano de Guglielmo*, "Catechol-O-Methyltransferase Inhibition and Alcohol Use Disorder: Evaluating the Efficacy of Tolcapone in Ethanol-Dependent Rats" Neuropharm. 2023, 242, 109770. DOI: 10.1016/J.NEUROPHARM.2023.109770

270. Austin Wang, Kyle Barcus, and Seth M. Cohen*, "Quantifying Ligand Binding to the Surface of Metal-Organic Frameworks" J. Am Chem. Soc. 2023, 145, 16821-16827. DOI: 10.1021/JACS.3C04892

269. Guorui Cai, Amanda Chen, Sharon Lin, Dong Ju Lee, Kunpeng Yu, John Holoubek, Yijie Yin, Anthony Mu, Ying Meng, Ping Liu, Seth Cohen*, Tod Pascal*, and Zheng Chen*, "Unravelling Ultrafast Li-ion Transport in Functionalized Metal-organic Framework Based Battery Electrolytes" Nano Lett. 2023, 23, 7062-7069. DOI: 10.1021/ACS.NANOLETT.3C01825

268. Guorui Cai, Shatila Sarwar, Dong J. Lee, Seth Cohen, and Zheng Chen*, "Metal-organic Frameworks for Advanced Battery Chemistries" Encyclopedia of Materials: Electronics 2023, 3, 226-236. DOI: 10.1016/B978-0-12-819728-8.00033-4

267. Samuel E. Griffin, Grant P. Domecus, and Seth M. Cohen*, "Experimental Approaches for the Synthesis of Low-Valent
Metal-Organic Frameworks from Multitopic Phosphine Linkers" J. Vis. Exp. 2023, e65317. DOI: 10.3791/65317

266.  Samuel E. Griffin, Grant P. Domecus, Clarissa E. Flores, R. Eric Sikma, Lauren Benz, and Seth M. Cohen*, "A Coordination Polymer of Vaska’s Complex as a Heterogeneous Catalyst for the Reductive Formation of Enamines from Amides" Angew. Chem. Intl. Ed. 2023, 62, e202301611. DOI: 10.1002/ANIE.202301611

265. Hyeonglim Seo, Alysia J. Kohlbrand, Ryjul W. Stokes, Jeewon Chung, and Seth M. Cohen*, "Masking thiol reactivity with thioamide, thiourea, and thiocarbamate-based MBPs" Chem. Commun. 2023, 59, 2283-22865. DOI: 10.1039/D2CC06596G

264. Johannes Karges and Seth M. Cohen*, "Rhenium(V) Complexes as Cysteine-Targeting Coordinate Covalent Warheads" J. Med. Chem. 2023, 66, 3088-3105. DOI: 10.1021/ACS.JMEDCHEM.2C02074

263. Conor B. O’Herin, Yuta W. Moriuchi, Troy A. Bemis, Alysia J. Kohlbrand, Michael D. Burkart,* and Seth M. Cohen*, "Development of Human Carbonic Anhydrase II Heterobifunctional Degraders" J. Med. Chem. 2023, 66, 2789-2803. DOI: 10.1021/ACS.JMEDCHEM.2C01843

262. Johannes Karges and Seth M. Cohen*, "Enantioselective Inhibition of the SARS-CoV-2 Main Protease with Rhenium(I) Picolinic Acid Complexes" Chem. Sci. 2023, 14, 711-720. DOI: 10.1039/D2SC05473F

261. Ryjul Stokes, Alysia Kohlbrand, Hyeonglim Seo, Banumathi Sankaran, Johannes Karges, and Seth M. Cohen*, "Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors" ACS Med. Chem. Lett. 2023, 14, 75-82. DOI: 10.1021/ACSMEDCHEMLETT.2C00434.


260. Kyle Barcus, Po-An Lin, Yilong Zhou, Gaurav Arya, and Seth M. Cohen*, "The Influence of Polymer Characteristics on the Self-Assembly of Polymer-Grafted MOF Particles" ACS Nano 2022, 16, 18168-18177.  DOI: 10.1021/ACSNANO.2C05175

259. Prantik Mondal and Seth M. Cohen*, "Self-healing Mixed Matrix Membranes Containing Metal-Organic Frameworks" Chem. Sci. 2022, 13, 12127-12135.  DOI: 10.1039/D2SC04345A

258. Dong Ju Lee, Xiaolu Yu, Ronald E. Sikma, Mingqian Li, Seth M. Cohen, Guorui Cai, and Zheng Chen*, "Holistic Design Consideration of Metal-Organic Framework-Based Composite Membranes for Lithium-Sulfur Batteries" ACS App. Mater. Inter. 2022, 14, 34742-34749.  DOI: 10.1021/ACSAMI.2C08404

257. Ryan A. Dodson, Junkil Park, Jihan Kim, Matthew J. Cliffe, and Seth M. Cohen*, "Tethering Effects in Oligomer-Based Metal–Organic Frameworks" Inorg. Chem. 2022, 61, 12284-12292.  DOI: 10.1021/ACS.INORGCHEM.2C01567

256. Ronald E. Sikma, Krista P. Balto, Joshua S. Figueroa*, and Seth M. Cohen*, "Metal-Organic Frameworks with Low-Valent Metal Nodes" Angew. Chem. Int. Ed. 2022, 61, e202206353.  DOI: 10.1002/ANIE.202206353

255. Hyeonglim Seo, Moritz K. Jackl, Mark Kalaj, and Seth M. Cohen*, "Developing Metal-binding Isosteres of 8-Hydroxyquinoline as Metalloenzyme Inhibitor Scaffolds" Inorg. Chem. 2022, 61, 7631-7641.  DOI: 10.1021/ACS.INORGCHEM.2C00891

254. Johannes W. M. Osterrieth, et al., Seth M. Cohen, and David Fairen-Jimenez*, "How Reproducible are Surface Areas Calculated from the BET Equation?" Adv. Mater. 2022, 2201502.  DOI: 10.1002/ADMA.202201502

253. Johannes Karges, Ryjul W. Stokes, and Seth M. Cohen*, "Computational Prediction of the Binding Pose of Metal-Binding Pharmacophores" ACS Med. Chem. Lett. 2022, 13, 428-435.  DOI: 10.1021/ACSMEDCHEMLETT.1C00584

252. Johannes Karges and Seth M. Cohen*, "Preorganized Homochiral Pyrrole-Based Receptors That Display Enantioselective Anion Binding" Eur. J. Org. Chem. 2022, e202101346.  DOI: 10.1002/EJOC.202101346

251. Moritz K. Jackl, Hyeonglim Seo, Johannes Karges, Mark Kalaj, and Seth M. Cohen*, "Salicylate Metal-Binding Isosteres as Fragments for Metalloenzyme Inhibition" Chem. Sci. 2022, 13, 2128-2136.  DOI: 10.1039/D1SC06011B

250. Ronald E. Sikma and Seth M. Cohen*, "Metal-Organic Frameworks with Zero and Low Valent Metal Nodes Connected by Tetratopic Phosphine Ligands" Angew. Chem. Int. Ed. 2022, 61, e2021154 (highlighted as a 'Science Concentrate' on Jan. 17, 2022 by C&E News).  DOI: 10.1002/ANIE.202115454

249. Jie Zhu, Laura Samperisi, Mark Kalaj, Jerika A. Chiong, Jake B. Bailey, Zhiyin Zhang, Chung-Jui Yu, R. Eric Sikma, Xiaodong Zou, Seth M. Cohen, Zhehao Huang*, and F. Akif Tezcan*, "Metal-Hydrogen-Pi-Bonded Organic Frameworks" Dalton Trans. 2022, 51, 1927-1935.  DOI: 10.1039/D1DT04278E

248. Jessica C. Moreton, Jin Xiang Low, Katrina C. Penticoff, Seth M. Cohen, and Lauren Benz*, "An X-ray Photoelectron Spectroscopy Study of Postsynthetic Exchange in UiO-66" Langmuir 2022, 38, 1589-1599.  DOI: 10.1021/ACS.LANGMUIR1C03015

247. Sergio Ayala Jr. and Seth M. Cohen*, "PolyMOFs: Molecular Level Integration of MOFs and Polymers" Chapter 2 in Hybrid Metal-Organic Framework and Covalent Organic Framework Polymers, Smart Materials No. 39, published by the Royal Society of Chemistry, Ed. Bo Wang, 2022, 6-28.  DOI: 10.1039/9781839163456


246. Samar S. Sandhu, Yugender Goud Kotagiri, P. U. Ashvin Iresh Fernando, Mark Kalaj, Nicholas Tostado, Hazhir Teymourian, Erik M. Alberts, Travis Thornell, Glen Jenness, Steven P. Harvey, Seth M. Cohen*, Lee C. Moores*, and Joseph Wang*, "Green MIP-202(Zr) Catalyst: Degradation and Thermally Robust Biomimetic Sensing of Nerve Agents" J. Am. Chem. Soc. 2021, 143, 18261-18271. DOI: 10.1021/JACS.1C08356

245. Johannes Karges*, Hyeonglim Seo, and Seth M. Cohen, "Synthesis of Tetranuclear Rhenium(I) Tricarbonyl Metallacycles" Dalton Trans. 2021, 50, 16147-16155.  DOI: 10.1039/D1DT02435C

244. Hyeonglim Seo, Kathleen Prosser, Mark Kalaj, Johannes Karges, Benjamin L. Dick, and Seth M. Cohen*, "Evaluating Metal-ligand Interactions of Metal-binding Isosteres Using Model Complexes" Inorg. Chem. 2021, 60, 17161-17172.  DOI:  10.1021/ACD.INORGCHEM.1C02433

243. Dominga Rogolino*, Lieve Naesens*, Jennifer Bartoli, Mauro Carcelli, Laura De Luca, Giorgio Pelosi, Ryjul W. Stokes, Ria Van Berwaer, Serena Vittorio, Annelies Stevaert, and Seth M. Cohen, "Exploration of the 2,3-Dihydroisoindole Pharmacophore for Inhibition of the Influenza Virus PA Endonuclease" Bioorg. Chem. 2021, 116, 105388.  DOI: 10.1016/J.BIOORG.2021.105388

242. Marcello B. Solomon, Carol Hua, Bun Chan, Tamara L. Church, Seth M. Cohen, Clifford P. Kubiak, Katrina A. Jolliffe, and Deanna M. D’Alessandro*, "The Electrochemical Reduction of a Flexible Mn(II) Salen-Based Metal-Organic Framework" Dalton Trans. 2021, 50, 12821-12825.  DOI: 10.1039/D1DT02589A

241. Seth M. Cohen* and Nathaniel L. Rosi*, "Postsynthetic Modification of Metal−Organic Frameworks" Inorg. Chem. 2021, 60, 11703-11705. (Guest Editor Introduction to Themed Issue). DOI: 10.1021/ACS.INORGCHEM.1C02159958

240. Kelly Hunter, Jackson Wagner, Mark Kalaj, Seth M. Cohen, Wei Xiong*, and Francesco Paesani*, "Simulation Meets Experiment: Unraveling the Properties of Water in Metal-Organic Frameworks Through Vibrational Spectroscopy" J. Phys. Chem. C 2021, 125, 12451-12460.  DOI: 10.1021/ACS.JPCC.1C03145

239. Johannes Karges* and Seth M. Cohen*, "Metal Complexes as Antiviral Agents for SARS-CoV-2" ChemBioChem 2021, 22, 2600-2607.  DOI: 10.1002/cbic.202100186

238. Ashleigh Castner, Ben A. Johnson, Seth M. Cohen, Sascha Ott*, "Mimicking the Electron Transport Chain and Active Site of [FeFe] Hydrogenases in one Metal-Organic Framework: Factors that Influence Charge Transport" J. Am. Chem. Soc. 2021, 21, 7991-7999.  DOI: 10.1021/JACS.1C01361

237. Huan Zhang, Kundi Yang, Abbie Steinbrunner, Cecily Pryor, Maya Vulcan, Claire Kemp, Diego Orea, Chathura Paththamperuma, Zishuo Cheng, Allie Y. Chen, Seth M. Cohen, Richard C. Page, David L. Tierney, Michael W. Crowder*, "Spectroscopic and Biochemical Characterization of Metallo-b-lactamase IMP-1 with Dicarboxylic, Sulfonyl, and Thiol Inhibitors" Bioorg. Med. Chem. 2021, 40, 116183.  DOI: 10.1016/J.BMC.2021.116183

236. Kathleen E. Prosser, Alysia J. Kolhbrand, Heonglim Seo, Mark Kalaj, and Seth M. Cohen*, "19F-Tagged Metal Binding Pharmacophores for NMR Screening of Metalloenzymes" Chem. Commun. 2021, 57, 4934-4937.  DOI: 10.1039/D1CC01231B

235. Joseph M. Palomba, David M. Wirth, Jin Yeong Kim, Mark Kalaj, Evan M. Clarke, Gregory W. Peterson, Jonathan K. Pokorski, and Seth M. Cohen*, "Strong, Ductile MOF-Polyurethane Urea Composites" Chem. Mater. 2021, 33, 3164-3171.  DOI: 10.1021/ACS.CHEMMATER.0C04874

234. Ralph Freund, Stefano Canossa, Seth M. Cohen, Wei Yan, Hexiang Deng, Vincent Guillerm, Mohamed Eddaoudi, David G. Madden, David Fairen-Jimenez, Hao Lyu, Lauren K. Macreadie, Zhe Ji, Yuanyuan Zhang, Bo Wang, Frederik Haase, Christof Wöll, Orysia Zaremba, Jacopo Andreo, Stefan Wuttke, and Christian S. Diercks*, "25 years of Reticular Chemistry" Angew. Chem. Intl. Ed. 2021, 60, 23946-23974.  DOI: 10.1002/ANIE.202101644

233. Johannes Karges, Ryjul W. Stokes, and Seth M. Cohen*, "Metal Complexes for Therapeutic Applications" Trends Chem. 2021, 3, 523-534.  DOI: 10.1016/J.TRECHM.2021.03.006

232. Jin Yeong Kim, Kyle Barcus, and Seth M. Cohen*, "Controlled Two-Dimensional Alignment of Metal-organic Frameworks in Polymer Films" J. Am. Chem. Soc. 2021, 143, 3703-3706.  DOI: 10.1021/JACS.0C13459

231. Rebecca N. Adamek, Caitlin N. Suire, Ryjul W. Stokes, Monica K. Brizuela, Seth M. Cohen*, and Malcolm A. Leissring*, "Hydroxypyridinethione Inhibitors of Human Insulin-Degrading Enzyme" ChemMedChem 2021, 16, 1775-1787.  DOI: 10.1002/CMDC.202100111

230. Johannes Karges, Mark Kalaj, Milan Gembicky, and Seth M. Cohen*, "Re(I) Tricarbonyl Complexes as Coordinate Covalent Inhibitors for the SARS-CoV-2 Main Cysteine Protease" Angew. Chem. Intl. Ed. 2021, 60, 10716-10723.  DOI: 10.1002/ANIE.202016768

229. Jin Yeong Kim, Evan M. Clarke, and Seth M. Cohen*, "Current Trends in the Postsynthetic Modification of Framework Materials" Comprehensive Coordination Chemistry III 2021, 1, 1055-1073.  DOI: 10.1016/B978-0-08-102688-5.00087-8

228. Johannes Karges, Ryjul W. Stokes, and Seth M. Cohen*, "Photorelease of a Metal-Binding Pharmacophore from a Ru(II) Polypyridine Complex" Dalton Trans. 2021, 50, 2757-2765.  DOI: 10.1039/D0DT04290K

227. Yi-Sheng Lu, Sanahan Vijayakumar, Arnaud Chaix, Brian Pimentel, Kyle C. Bentz, Sheng Li, Adriano Chan, Charlotte Wahl, James Ha, Deborah Hunka, Gerry Boss, Seth M. Cohen, and Michael Sailor*, "Remote Detection of HCN, HF, and Nerve Agent Vapors Based on Self-Referencing, Dye-Impregnated Porous Silicon Photonic Crystals" ACS Sensors 2021, 6, 418-428.  DOI: 10.1021/ACSSENSORS.0C01931


226. Xinyi Gong, Karthikeyan Gnanasekaran, Zhijie Chen, Lee Robison, Megan C. Wasson, Kyle C. Bentz, Seth M. Cohen*, Omar K. Farha*, and Nathan C. Gianneschi*, "Insights into the Structure and Dynamics of Metal–Organic Frameworks via Transmission Electron Microscopy" J. Am. Chem. Soc. 2020, 142, 17224-17235.  DOI: 10.1021/JACS.0C08773

225. Kyle C. Bentz, Karthikeyan Gnanasekaran, Jake B. Bailey, Sergio Ayala Jr., F. Akif Tezcan, Nathan C. Gianneschi*, and Seth M. Cohen*, "Inside polyMOFs: Layered Structures in Polymer-Based Metal-Organic Frameworks" Chem. Sci. 2020, 11, 10523-10528.  DOI: 10.1039/D0SC03651J

224. Lucy Lin, Margaret Olson, Takashi Sugane, Lewis Turner, Margarita Tararina, Alexander L. Nielsen, Elbek Kurbanov, Sabine Pellett, Eric Johnson, Seth M. Cohen, Karen Allen, and Kim Janda*, "A Catch and Anchor Approach to Combat both Toxicity and Longevity of Botulinum Toxin A" J. Med. Chem. 2020, 63, 11100-11120.  DOI: 10.1021/ACS.JMEDCHEM.0C01006

223. Kyle S. Barcus and Seth M. Cohen*, "Free-Standing Metal-Organic Framework (MOF) Monolayers by Self-Assembly of Polymer-Grafted Nanoparticles" Chem. Sci. 2020, 11, 8433-8437.  DOI: 10.1039/D0SC03318A

222. Rebecca N. Adamek, Paul Ludford, Stephanie M Duggan, Yitzhak Tor*, and Seth M. Cohen*, "Identification of Adenosine Deaminase Inhibitors by Metal-binding Pharmacophore Screening" ChemMedChem 2020, 15, 2151-2156.  DOI: 10.1002/CMDC.202000271

221. Caitlyn A. Thomas, Zishuo Cheng, Kundi Yang, Elle Hellwarth, Cole J. Yurkiewicz, Faith M. Baxter, Sarah A. Fullington, Spencer A. Klinsky, Jen L. Otto, Allie Y. Chen, Seth M. Cohen, and Michael W. Crowder*, "Probing the mechanisms of inhibition for various inhibitors of metallo-β- lactamases VIM-2 and NDM-1" J. Inorg. Biochem. 2020, 210, 111123.  DOI: 10.1016/J.JINORGBIO.2020.111123

220. Mark Kalaj and Seth M. Cohen*, "Postsynthetic Modification: An Enabling Technology for the Advancement of Metal-Organic Frameworks" ACS Cent. Sci. 2020, 6, 1046-1057.  DOI: 10.1021/ACSCENTSCI.0C00690

219. Mark Kalaj, Kathleen E. Prosser, and Seth M. Cohen*, "Room Temperature Aqueous Synthesis of UiO-66 Derivatives via Postsynthetic Exchange" Dalton Trans. 2020, 49, 8841-8845.  DOI: 10.1039/D0DT01939A

218. Benjamin L. Dick, Ashay Patel, and Seth M. Cohen*, "Effect of Heterocycle Content on Metal Binding Isostere Coordination" Chem. Sci. 2020, 11, 6907-6914.  DOI: 10.1039/d0SC02717K

217. Paulo G. M. Mileo, Shichen Yuan, Sergio Ayala, Pu Duan, Rocio Semino, Seth M. Cohen*, Klaus Schmidt-Rohr*, and Guillaume Maurin*, " Structure of the Polymer Backbones in polyMOF Materials" J. Am. Chem. Soc. 2020, 142, 10863-10868.  DOI: 10.1021/JACS.0C04546

216. Kathleen E. Prosser, Ryjul W. Stokes, and Seth M. Cohen*, "Evaluation of 3-Dimensionality in Existing Approved and Experimental Drug Space" ACS Med. Chem. Lett. 2020, 11, 1292-1298.  DOI: 10.1021/ACSMEDCHEMLETT.0C00121

215. Mark Kalaj and Seth M. Cohen*, "Spray Coating of Catalytically Active MOF-Polythiourea through Postsynthetic Polymerization" Angew. Chem. Intl. Ed. 2020, 59, 13984-13989.  DOI: 10.1002/ANIE.202004205

214. Allie Y. Chen, Caitlyn Thomas, Pei W. Thomas, Kundi Yang, Zishou Cheng, Walter Fast*, Michael Crowder*, and Seth M. Cohen*, "Iminodiacetic Acid as a Novel Metal-Binding Pharmacophore for New Delhi Metallo-β-lactamase Inhibitor Development" ChemMedChem 2020, 15, 1272-1282.  DOI: 10.1002/CMDC.202000123

213. Jerika Chiong, Jie Zhu, Jake Bailey, Mark Kalaj, Rohit Subramanian, Wenqian Xu, Seth M. Cohen, F. Akif Tezcan*, "An Exceptionally Stable Metal-Organic Framework Constructed from Chelate-based Metal-Organic Polyhedra" J. Am. Chem. Soc. 2020, 142, 6907-6912.  DOI: 10.1021/JACS.0C01626

212. Jessica C. Moreton, Joseph M. Palomba, and Seth M. Cohen*, "Liquid-Phase Applications of Metal-Organic Framework Mixed-Matrix Membranes Prepared from Poly(ethylene-co-vinyl acetate)" ACS App. Poly. Mater. 2020, 2, 2063-2069.  DOI: 10.1021/ACSAPM.0C00230

211. Joseph M. Palomba, Mark Kalaj, and Seth M. Cohen*, "High-throughput Screening of MOFs for Breakdown of V-series Nerve Agents" ACS App. Mater. Inter. 2020, 12, 14672-14677.  DOI: 10.1021/ACSAMI.9B21693

210. Christine N. Morrison, Kathleen E. Prosser, Ryjul W. Stokes, Anna Cordes, Nils Metzler-Nolte, and Seth M. Cohen*, "Expanding Medicinal Chemistry into 3D Space: Metallofragments as 3D Scaffolds for Fragment-Based Drug Discovery" Chem. Sci. 2020, 11, 1216-1225 (selected as 'Pick of the Week' Jan. 15, 2020 by Chem. Sci.).  DOI: 10.1039/C9SC05586J 

209. Mark Kalaj, Kyle C. Bentz, Sergio Ayala Jr., Joseph M. Palomba, Kyle S. Barcus, Yuji Katayama, and Seth M. Cohen*, "MOF-Polymer Hybrid Materials: From Simple Composites to Tailored Architectures" Chem. Rev. 2020, 120, 8267-8302.  DOI: 10.1021/ACS.CHEMREV.9B00575

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